Naja nubiae venom ameliorate hepatorenal toxicity induced by Gentamicin in rats

Background: In developing countries, there is no doubt that acute kidney injury and chronic liver diseases have a major impact on health. Different venom components are gaining renewed interest as potential sources of new pharmacological compounds relevant for human therapeutics. Aim: The present study was designed to evaluate the therapeutic efficacy crude extract Egyptian spitting cobra (Naja nubiae) against gentamycin–induced nephrotoxicity hepatotoxicity in rats. Methods: Eighteen male Wistar rats were divided into three groups, control, gentamycin, extract. hepatorenal toxicity model induced by gentamycin (80 mg/kg, intraperitoneal) 8 days. Results: LD50 0.2mg/kg. group showed significant decrease enzymes, urea, uric acid, creatinine, malondialdehyde meanwhile glutathione reduced catalase levels increased. Histological examination mild protective with less extensive degenerative changes tissues grou Conclusion: results investigation administration proved -induced dysfunction maintain normal functional status normalized antioxidant system.